THE MAIN CLINICAL TYPES OF LIVER INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS
DOI:
https://doi.org/10.52754/16948610_2025_1_4Keywords:
systemic lupus erythematosus, SLE, liver damage, lupus hepatiteAbstract
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder characterized by systemic inflammation affecting almost all organs and tissues of the body. The aim of this study was to evaluate the frequency and clinical manifestations of liver involvement in 78 patients diagnosed with SLE. The study methods included clinical examination, biochemical blood tests (measuring transaminases, bilirubin, and albumin levels), serological tests to identify specific antibodies, and liver ultrasound to assess its condition. Liver involvement was identified in 41 (52.5%) patients. The clinical forms of liver pathology observed in these patients included lupus hepatitis in 19 (46.3%), drug-induced hepatitis in 8 (19.5%), chronic viral hepatitis B and C in 2 (4.9%), secondary antiphospholipid syndrome in 3 (7.3%), non-alcoholic fatty liver disease in 6 (14.6%), and cirrhosis in 3 (7.3%) cases. These findings highlight the importance of early detection and regular monitoring of liver abnormalities in SLE patients, which will allow for optimized treatment and prevention strategies, improving the overall prognosis of the disease.
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