APPLICATION OF NANOPARTICLES IN THE TREATMENT OF BURN WOUNDS

Abstract

Regenerative activity of the skin is very important for the timely healing of burn wounds. Zinc oxide and silver nanoparticles possess antibacterial and wound-healing properties. Although today the pharmaceutical market offers a wide range of topical agents for burn wound treatment, it must be acknowledged that the optimal level of wound-healing efficacy has not yet been achieved. The purpose of the study: to study the healing of burn wounds in adults and children with second-degree burns using zinc oxide and silver nanoparticles and the youthful characteristics of skin regenerative activity. Research objects: 1) to synthesize nanoparticles of zinc and silver oxide, determine their structure, composition, and antibacterial properties; 2) to develop dressings containing nanoparticles of zinc and silver oxide for local treatment of second-degree burns in children and adults; 3) to determine the effectiveness of dressings containing zinc and silver oxide nanoparticles in treating second-degree burn wounds compared to other drugs. In this study, experiments were conducted to synthesize zinc oxide and silver nanoparticles for preparing antibacterial dressings for burn wound treatment. The zinc oxide and silver nanoparticles were synthesized using a chemical method. The structural and phase compositions of the synthesized nanoparticles were determined using X-ray diffraction analysis (XRD) and infrared spectroscopy. The preparation of dressing materials containing zinc oxide and silver nanoparticles for burn wound treatment involves several stages aimed at ensuring sterility, uniformity, and effectiveness of the final product. The antimicrobial activity of zinc oxide and silver nanoparticles was assessed using the disk diffusion method on Mueller-Hinton agar in accordance with the guidelines specified in Order No. 729 of the Ministry of Health of the Kyrgyz Republic dated October 25, 2018. Age characteristics of skin regeneration: the skin's ability to regenerate is generally higher in children than in adults, which is due to higher metabolism, improved microcirculation, and higher cellular proliferation. As a result, wound healing processes in children are faster and less complicated. In adults, the regeneration process is slower, which is due to age-related changes in the body, such as decreased cell function, impaired microcirculation, and general age-related changes in skin tissue.