COMPARATIVE EFFECTIVENESS OF THIAZIDE AND THIAZIDE-LIKE DIURETICS IN THE TREATMENT OF ARTERIAL HYPERTENSION ON THE EXAMPLE OF THE MEDICAL CENTER “CLINIC OSH”

Authors

  • Askar Irisov Kyrgyz State Medical Institute of Retraining and Advanced Training named after S.B. Daniyarova https://orcid.org/0000-0002-1000-3016
  • Kamchybek Isabaev Director of the Osh Clinic Medical Center Kyrgyz Republic, Osh
  • Gulzada Zhamilova Coordinator of the project “Effective management and prevention of noncommunicable diseases in the Kyrgyz Republic”

DOI:

https://doi.org/10.52754/16948610_2024_2_6

Keywords:

тиазид жана тиазид сымал диуретиктер, индап, гидрохлоротиазид, гипертония

Abstract

This paper examines the comparative effectiveness of the use of thiazide (hydrochlorothiazide) and thiazide-like (indap) diuretics in the treatment of arterial hypertension in separate groups of patients at the Osh clinic. It was found that indap, compared with hydrochlorothiazide, had a pronounced prolonged antihypertensive effect, a minimal effect on the levels of lipids and carbohydrates in the blood, as well as a nephroprojective property.

References

Tamargo J., Segura J., Ruilope L.M. Diuretics in the treatment of hypertension. Part 1: thiazide and thi¬azide-like diuretics. Expert Opin Pharmacother. 2014;15(4):527-47. DOI:10.1517/14656566. 2014.879118. DOI: https://doi.org/10.1517/14656566.2014.879118

Williams B., Mancia G., Spiering W., et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-3104. DOI:10.1093/eurheartj/ehy339. DOI: https://doi.org/10.1093/eurheartj/ehy439

Rubricator of clinical guidelines of the Ministry of Health of the Russian Federation: clinical guidelines "Arterial hypertension in adults" [cited by Nov 23, 2020]. Available from: http://cr.rosminzdrav.ru/recomend/687 (In Russ.).

Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials. J Hy¬pertens. 2014;32(12):2285-95. DOI:10.1097/HJH.0000000000000378. DOI: https://doi.org/10.1097/HJH.0000000000000378

Weidmann P. Metabolic profile of indapamide sustained-release in patients with hypertension: data from three randomised double-blind studies. Drug Saf. 2001;24(15):1155-65. DOI:10.2165/00002018-200124150-00006. DOI: https://doi.org/10.2165/00002018-200124150-00006

Marre M., Puig J.G., Kokot F., et al. Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study. J Hypertens. 2004;22(8):1613-22. DOI:10.1097/01.hjh.0000133733.32125.09. DOI: https://doi.org/10.1097/01.hjh.0000133733.32125.09

Bahtiyar G., Gutterman D., Lebovitz H. Heart Failure: a Major Cardiovascular Complication of Diabetes Mellitus. Curr Diab Rep. 2016;16(11):116. DOI:10.1007/s11892-016-0809-4. DOI: https://doi.org/10.1007/s11892-016-0809-4

Zhang Y., Agnoletti D., Wang J.G., et al. Natriuresis and blood pressure reduction in hypertensive pa¬tients with diabetes mellitus: the NESTOR study. J Am Soc Hypertens. 2015;9(1):21-8. DOI:10.1016/j.jash.2014.10.003. DOI: https://doi.org/10.1016/j.jash.2014.10.003

Beckett N.S., Peters R., Fletcher A.E., et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358(18):1887-98. DOI:10.1056/NEJMoa0801369. DOI: https://doi.org/10.1056/NEJMoa0801369

Roush G.C., Abdelfattah R., Song S., et al. Hydrochlorothiazide and alternative diuretics versus renin-angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis. J Hypertens. 2018;36(6):1247-55. DOI:10.1097/HJH.0000000000001691. DOI: https://doi.org/10.1097/HJH.0000000000001691

Vinereanu D., Dulgheru R., Magda S., et al. The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: results of a randomized trial. Am Heart J. 2014;168(4):446-56. DOI:10.1016/j.ahj.2014.06.010. DOI: https://doi.org/10.1016/j.ahj.2014.06.010

Campbell DB. The possible mode of action of indapamide: a review. Current Medical Research and Opinion. 1983;8(Suppl 3):9–24. DOI:10.1185/03007998309109832. DOI: https://doi.org/10.1185/03007998309109832

Pareek AK, Messerli FH, Chandurkar NB, Dharmadhikari SK, Godbole AV, Kshirsagar PP et al. Efficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring. Journal of the American College of Cardiology. 2016;67(4):379–89. DOI: 10.1016/j.jacc.2015.10.083. DOI: https://doi.org/10.1016/j.jacc.2015.10.083

Tereshchenko S.N., Dzhaiani N.A., Akimov A.E., Gnidkina N.A., Kochetov A.G. Indapamide retard in complex therapy of patients with chronic heart failure and arterial hypertension. Cardiovascular Therapy and Prevention. 2010;9(2):43–7.

Zillich AJ, Garg J, Basu S, Bakris GL, Carter BL. Thiazide Diuretics, Potassium, and the Development of Diabetes: A Quantitative Review. Hypertension. 2006;48(2):219–24. DOI: 10.1161/01. HYP.0000231552.10054. DOI: https://doi.org/10.1161/01.HYP.0000231552.10054.aa

Shafi T, Appel LJ, Miller ER, Klag MJ, Parekh RS. Changes in Serum Potassium Mediate Thiazide-Induced Diabetes. Hypertension. 2008;52(6):1022–9. DOI: 10.1161/HYPERTENSIONAHA. 108.119438. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.108.119438

Downloads

Published

2024-06-27

How to Cite

Irisov , A., Isabaev , K., & Zhamilova , G. (2024). COMPARATIVE EFFECTIVENESS OF THIAZIDE AND THIAZIDE-LIKE DIURETICS IN THE TREATMENT OF ARTERIAL HYPERTENSION ON THE EXAMPLE OF THE MEDICAL CENTER “CLINIC OSH”. Bulletin of Osh State University, (2), 52–58. https://doi.org/10.52754/16948610_2024_2_6

Issue

No. 2 (2024): Bulletin of Osh State University

Section

MEDICINE

License

Copyright (c) 2024 The Author(s)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.