РЕДАКТИРОВАНИЕ ГЕНОМА НА ОСНОВЕ НАНОУСТРОЙСТВ ДЛЯ ПОВЫШЕНИЯ СТАБИЛЬНОСТИ И ЭФФЕКТИВНОСТИ CRISPR/CAS9
DOI:
https://doi.org/10.52754/16948688_2022_1_8Ключевые слова:
crispr/cas, нанотехнологии, crispr/cas9, доставкаАннотация
С тех пор, как десять лет назад важность CRISPR и CRISPR-ассоциированной системы (Cas) в области модификации генома возросла. Ограниченная эффективность внутриклеточной доставки этого метода затрудняет транспортировку полезных веществ Cas и sgRNA, несмотря на его адаптивность. Наноматериалы, включая липосомы, полимеры, наночастицы золота и неорганические наночастицы, успешно использовались для переноса генов. Здесь мы кратко рассмотрим множество систем доставки CRISPR / Cas и связанные с ними трудности, затем рассмотрим различные нанотехнологические способы доставки CRISPR / Cas и рассмотрим многочисленные проблемы, с которыми сталкивается редактирование генома растений на основе CRISPR. В нем также рассматривались проблемы, связанные с внедрением CRISPR/Cas9 с использованием нанотехнологий, и регионы, на которые необходимо ориентироваться, чтобы извлечь выгоду из этого подхода к редактированию
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